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MYP_167842
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Basic Information
Kunitzin-OS
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
17 amino acids
C88H141N25O19S2
Standard
Sequence
AVNIPFKVHLRCKAAFC
Physicochemical Analysis
1917.35 Da
9.51
2.86
2.59
0.1683
0.71
0.38
0.17
42.39
97.65
0.1176
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.84
-4.17
26.0
25.0
60.0
134.0
4.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0052362 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli
20 μM
MIC
PaperKunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
RECORD: Rec_0080318 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Antimicrobial Antibacterial Anti-Gram-negative
Esxherichia coli
20 μM
MIC
RECORD: Rec_0109619 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
20 μM
MIC
PMID27311856 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27311856/
RECORD: Rec_0231217 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory
chymotrypsin
329 μM
Ki
RECORD: Rec_0366402 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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