Peptide Database

Peptide NameCADY-1d (SEQ ID No: 5)

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H196N38O22

DescriptionStandard

        GLWRALWRGLRSLWKLKRKV
    

Molecular Weight2523.08 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.3379

GRAVY Index-0.45

Hydrophobic Moment 0.92

Boman Index-0.22

Instability Index75.94

Aliphatic Index 117.00

Aromaticity 0.1500

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1009.48

LogP -3.62

H-bond Donors 40.0

H-bond Acceptors 29.0

Rotatable Bonds 85.0

Heavy Atoms 180.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010727 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anticancer

PaperSelf-assembled peptide (CADY-1) improved the clinical application of doxorubicin.; Modeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo. PMID22688249;23000699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22688249/ PatentUS7943581B2

RECORD: Rec_0042993 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

RECORD: Rec_0272648 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermCysteamide group

Bio-Activity Profile

Function

Drug Delivery Vehicle Cell-penetrating peptide

RECORD: Rec_0416832 VERIFIED: NO

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetHeLa; HS-68 cells

MethodCellular uptake assay