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MYP_167767
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Basic Information
orphanin FQ/nociceptin
Binding / Molecular interaction ▸ Binding activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
17 amino acids
C79H129N27O22
Standard
Sequence
FGGFTGARKSARKLANQ
Physicochemical Analysis
1809.04 Da
12.00
3.76
3.55
0.2211
-0.69
0.69
-0.19
-2.75
40.59
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
831.40
-11.06
30.0
26.0
62.0
128.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0299456 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Receptor-binding
RP-HPLC
Mouse Plasma, in vitro; 3840 s
PMID17532097 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17532097/
RECORD: Rec_0340538 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0372535 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Nociceptin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator Growth regulation Development regulation Receptor modulation ACE inhibitory
Experimental: 64±1 minutes; /3840 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Nociceptin (Homo sapiens): PMID 12950177##17532097 PMID12950177;17532097 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12950177/
RECORD: Rec_0403597 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Opioid
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID7566152 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7566152/
RECORD: Rec_0427003 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Nociceptin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation
Experimental: 64±1 minutes; /3840 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Nociceptin (Bos taurus): PMID 9521323##17532097 PMID9521323;17532097 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9521323/
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