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MYP_167767
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Basic Information
orphanin FQ/nociceptin
Binding / Molecular interaction ▸ Binding activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
17 amino acids
C79H129N27O22
Standard
Sequence
FGGFTGARKSARKLANQ
Physicochemical Analysis
1809.04 Da
12.00
3.76
3.55
0.2211
-0.69
0.69
-0.19
-2.75
40.59
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
831.40
-11.06
30.0
26.0
62.0
128.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000706 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Nociceptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
opioid receptor
PaperReinscheid R. K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R. A., Bunzow J. R., Grandy D. K., Langen H., Monsma F. J., Civelli O.. Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor. Science, 270 (5237), 792-794, 1995.
RECORD: Rec_0052984 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Opioid
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID7481766 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7481766/
RECORD: Rec_0078749 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Opioid
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID7481766 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7481766/
RECORD: Rec_0089752 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]; Sus scrofa [Animal]; Homo sapiens [Animal]; Bos taurus [Animal]; Mus musculus [Animal]
10116; 9823; 9606; 9913; 10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0129995 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Nociceptin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Growth regulation Development regulation ACE inhibitory
Experimental: 64±1 minutes; /3840 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Nociceptin (Sus scrofa): PMID 7481766##17532097 PMID7481766;17532097 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7481766/
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