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MYP_167762
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C116H179N37O25
Standard
Sequence
FIHHIFRGIVHAGRSIGRFLTG
Physicochemical Analysis
2491.89 Da
12.00
3.02
2.67
0.1373
0.45
0.78
0.22
39.66
106.36
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
986.62
-7.20
37.0
31.0
80.0
178.0
6.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0393867 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Piscidin
45352
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Not included yet
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HT1080
26.01 M
IC50
PaperSynergistic Treatment of Breast Cancer by Combining the Antimicrobial Peptide Piscidin with a Modified Glycolipid PMID39130564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/39130564/
RECORD: Rec_0396044 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Piscidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Human erythrocytes
0.78-6.25 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/18827353/ PMID18827353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18827353/
RECORD: Rec_0401399 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Piscidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11713517/ PMID11713517 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11713517/
RECORD: Rec_0404672 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Piscidin
45352
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Not included yet
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
A549
21.6 M
IC50
PaperSynergistic Treatment of Breast Cancer by Combining the Antimicrobial Peptide Piscidin with a Modified Glycolipid PMID39130564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/39130564/
RECORD: Rec_0416203 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
pleurocidin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial pleurocidin family Antibacterial Host defense
PaperPDB 2MCX structural record; NMR; chain A; residues 1-22
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