Peptide Database

Peptide NameSLAY-screened peptide P2450

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H159N25O27S

DescriptionStandard

        AALKCLLSLPVYPQRAADSF
    

Molecular Weight2163.54 Da

Isoelectric Point (pI)8.24

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0393

GRAVY Index0.52

Hydrophobic Moment 0.40

Boman Index0.18

Instability Index51.56

Aliphatic Index 112.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 827.64

LogP -6.22

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 66.0

Heavy Atoms 152.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303048 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/