Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length59 amino acids

Chemical FormulaC280H443N79O89S8

DescriptionStandard

        MPKYDDFDLNLKQVSNTDHKNPRITSLIACTPGTCNSKCPNTNWLCSNVCVTKTCWTCA
    

Molecular Weight6596.51 Da

Isoelectric Point (pI)8.21

Net Charge (pH 7.0)1.52

Net Charge (pH 7.4) 1.14

Charge Density (pH 7.0) 0.0257

GRAVY Index-0.43

Hydrophobic Moment 0.41

Boman Index-0.06

Instability Index34.10

Aliphatic Index 57.80

Aromaticity 0.0678

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2725.13

LogP -34.46

H-bond Donors 99.0

H-bond Acceptors 100.0

Rotatable Bonds 209.0

Heavy Atoms 456.0

Ring Count 11.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0061636 VERIFIED: NO

Provenance & Taxonomy

OrganismVagococcus fessus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence