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MYP_167710
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Basic Information
4330
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
20 amino acids
C91H140N26O30S3
Standard
Sequence
KGEAMHGQVDCSPGIWQLDC
Physicochemical Analysis
2174.44 Da
4.54
-2.17
-2.46
-0.1084
-0.40
0.21
0.07
31.38
58.50
0.0500
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
896.23
-9.45
31.0
32.0
70.0
150.0
4.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0046633 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
Qualitative inhibition
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0057750 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 10.0%, T 60.0%, C 30.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0118730 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0166128 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity
4 μM
IC50
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0205878 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
6.8 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. | Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A. | Arch Biochem Biophys. 2007 Feb 15;458(2):202-12. | DOI:10.1016/j.abb.2006.12.007 | PMID:17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
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