Peptide Database

Peptide NameSebelipase alfa

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC296H457N79O94S2

DescriptionStandard

        SGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPV
    

Molecular Weight6690.40 Da

Isoelectric Point (pI)5.14

Net Charge (pH 7.0)-3.36

Net Charge (pH 7.4) -3.71

Charge Density (pH 7.0) -0.0560

GRAVY Index-0.65

Hydrophobic Moment 0.46

Boman Index-0.02

Instability Index33.31

Aliphatic Index 73.00

Aromaticity 0.0833

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2767.89

LogP -27.98

H-bond Donors 94.0

H-bond Acceptors 95.0

Rotatable Bonds 216.0

Heavy Atoms 471.0

Ring Count 13.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310672 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyEnzyme

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme replacement

Half-Life5.4-6.6 min

PaperPubMed-linked source references: PMID:28197978; PMID:28179030; PMID:27878737; PMID:27876313; PMID:27816062; PMID:27799810; PMID:27649344; PMID:27576533; PMID:27376161 PMID28197978;28179030;27878737;27876313;27816062;27799810;27649344;27576533;27376161 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28197978/