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MYP_167547
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Basic Information
LP10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Metal-binding / iron acquisition ▸ Siderophore
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Tripeptidyl Peptidase II Inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044012 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
KKWβ2,2WKK
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid)
Bio-Activity Profile
Anticancer Cytotoxic
Ramos
7.9±0.3 μM
IC50
PMID22933412 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22933412/
RECORD: Rec_0044200 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oligo-acyl-lysyl
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
A=amino; l=lauric acid,alK=aminolauryl-lysine
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum W2
4.63 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID17307975 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17307975/
RECORD: Rec_0044623 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)16CO
Amidation
Ornithine at 1,2; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa MTCC 2295
25 μg/mL
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0046377 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)6CO
Amidation
Ornithine at 1,2; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Aspergillus niger ATCC 64028
>100 μg/mL
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0053835 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)8CO
Amidation
Ornithine at 1,2; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
methicillin-resistant Staphylococcus aureus ATCC BAA-1720
>100 μg/mL
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
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