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MYP_167547
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Basic Information
LP10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Metal-binding / iron acquisition ▸ Siderophore
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Tripeptidyl Peptidase II Inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250764 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oligo-acyl-lysyl
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
L=lauric acid
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum W2
3.54 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID17307975 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17307975/
RECORD: Rec_0252419 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Morpholine urea
Aldehyde
HPhe- homophenylalanine
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum W2
0.001 μM
IC50; Flourimetry (Hydrolysis of the fluorogenic substrate)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
RECORD: Rec_0252662 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
None
None
A=amino; l=lauric acid,alK=aminolauryl-lysine
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0258450 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
ornithine at 1,2
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
14.2
MIC
PMID22986997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22986997/
RECORD: Rec_0258829 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cyclopentanecarboxylic acid
32630
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
R=CH2CH(CH3)2
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum chloroquine sensitive
9.41 μM
IC50; Microscopy (Giemsa staining)
PMID18305429 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18305429/
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