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MYP_167547
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Basic Information
LP10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Metal-binding / iron acquisition ▸ Siderophore
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Tripeptidyl Peptidase II Inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0088454 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cyclopentanecarboxylic acid
32630
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
R=H
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum chloroquine sensitive
19.87 μM
IC50; Microscopy (Giemsa staining)
PMID18305429 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18305429/
RECORD: Rec_0089567 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)12CO
Amidation
Ornithine at 1,2; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis MTCC 2763
50 μg/mL
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0090225 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Benzyloxycarbonyl
Aldehyde
HPhe- homophenylalanine
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum W2
0.0082 μM
IC50; Microscopy (Giemsa staining)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
RECORD: Rec_0098044 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
KKWβ2,2WKK
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid)
Bio-Activity Profile
Anticancer Cytotoxic
Ramos
92±2 μM
IC50
PMID22933412 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22933412/
RECORD: Rec_0100642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cyclopentanecarboxylic acid
32630
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
R=CH2C6H5
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum chloroquine resistant
9.67 μM
IC50; Microscopy (Giemsa staining)
PMID18305429 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18305429/
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