Peptide Database

Peptide NameMegascoliakinin

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Membrane / Ion-channel modulation ▸ Ion channel modulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC60H92N18O13

DescriptionStandard

        RPPGFTPFRKA
    

Molecular Weight1273.49 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.2508

GRAVY Index-1.04

Hydrophobic Moment 0.30

Boman Index-0.25

Instability Index61.62

Aliphatic Index 9.09

Aromaticity 0.1818

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 498.00

LogP -4.06

H-bond Donors 17.0

H-bond Acceptors 16.0

Rotatable Bonds 35.0

Heavy Atoms 91.0

Ring Count 5.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114701 VERIFIED: YES

Provenance & Taxonomy

OrganismMegascolia flavifrons [Animal]

FamilyMegascoliakinin

Tax ID7437

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Cardiovascular Myotropic Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Activity1.6 μM

MethodKi

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0276945 VERIFIED: NO

Provenance & Taxonomy

OrganismMegascolia flavifrons [Animal]

FamilyBradykinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0289028 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic

RECORD: Rec_0407645 VERIFIED: YES

Provenance & Taxonomy

OrganismMegascolia flavifrons [Animal]

FamilyMegascoliakinin

Tax ID7437

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Cardiovascular Myotropic Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min