Peptide Database

Peptide NameHE-RK

Function Ontology

Anticancer ▸ Tumor-penetrating

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide ▸ Cell-penetrating

Delivery / Targeting ▸ Drug delivery vehicle ▸ Drug delivery

Delivery / Targeting ▸ Tumor targeting ▸ Tumor-targeting peptide

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC168H249N73O57

DescriptionStandard

        HEHEHEHEHEHEHEHEHEHEGGGGGRRRRRRGDK
    

Molecular Weight4203.23 Da

Isoelectric Point (pI)6.18

Net Charge (pH 7.0)-3.34

Net Charge (pH 7.4) -4.07

Charge Density (pH 7.0) -0.0982

GRAVY Index-3.05

Hydrophobic Moment 0.49

Boman Index-0.77

Instability Index83.51

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2118.14

LogP -26.33

H-bond Donors 75.0

H-bond Acceptors 63.0

Rotatable Bonds 147.0

Heavy Atoms 298.0

Ring Count 10.0

Amide Bonds 33.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0061536 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modspolymer conjugation in PM-HE-RK study

Bio-Activity Profile

Function

Cell-penetrating Drug delivery Tumor-targeting Tumor-penetrating

Target4T1; MCF-7; 4T1 mouse tumor model

MethodCellular internalization assay; tumor penetration assay