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MYP_167400
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Basic Information
RCG-P2G4
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
23 amino acids
C102H187N53O28
Standard
Sequence
RPRGRRGSRPSGAERRRRRAAAA
Physicochemical Analysis
2603.91 Da
12.00
8.76
8.56
0.3810
-1.98
0.51
-0.94
153.23
21.74
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1382.70
-21.45
55.0
37.0
88.0
183.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0036985 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 BaL
PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0040726 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 IIIB:inhibition of virus replication in PM1-CCR5 cells
2.2±0.51 μM
EC50
PaperPubMed PMID: 20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0098681 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | PM1-CCR5 cells
2.2±0.51 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0214415 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 Bal | PM1-CCR5 cells
10 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0257023 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
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