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MYP_167360
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Basic Information
TAT
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
9 amino acids
C53H106N30O11
Standard
Sequence
RKKRRQRRR
Physicochemical Analysis
1339.60 Da
12.00
7.76
7.55
0.8620
-4.26
0.55
-2.11
257.44
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
762.65
-9.62
31.0
19.0
52.0
94.0
0.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0257136 VERIFIED: NO
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat-derived peptide
11676.0
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HSV
Herpesvirus
PaperAntiviral Peptide and Antiviral Agent Evidence URLhttps://patents.google.com/patent/US20090258815/en PatentUS 20090258815
RECORD: Rec_0262861 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Φ, L-2-naphthylalanine,miniPEG, 8-amino-3,6-dioxaoctanoic acid
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24896852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24896852/
RECORD: Rec_0270975 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fused with protein C-terminus
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24878961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24878961/
RECORD: Rec_0271611 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
fluorescein with 6-aminohexanoic acid (Ahx) spacer
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID11087855 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087855/
RECORD: Rec_0284400 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Fluorescein/FITC labeling
None
N-term detail: Labelled with K-FITC or k-FITC at N-terminus; lowercase source residues at positions 1,2,3,4,5,6,7,8,9 denote stereochemical modification
Bio-Activity Profile
Cell-penetrating peptide
NIH-3T3
Fluorescence-based uptake assay
PMID21319732 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21319732/
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