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MYP_167360
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Basic Information
TAT
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
9 amino acids
C53H106N30O11
Standard
Sequence
RKKRRQRRR
Physicochemical Analysis
1339.60 Da
12.00
7.76
7.55
0.8620
-4.26
0.55
-2.11
257.44
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
762.65
-9.62
31.0
19.0
52.0
94.0
0.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105411 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-penetrating peptide
Human erythrocytes
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/23776609/ PMID23776609 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23776609/
RECORD: Rec_0124861 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Protein fusion
C-term detail: Bound with GFP
Bio-Activity Profile
Cell-penetrating peptide
Drosophila S2 cells
Cellular uptake assay
PMID11211880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11211880/
RECORD: Rec_0161090 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorescein/FITC labeling
None
N-term detail: Labelled with fluorescein
Bio-Activity Profile
Cell-penetrating peptide
RAW 264.7
Fluorescence-based uptake assay
PMID12450378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12450378/
RECORD: Rec_0177468 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus [Virus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Evidence URLhttps://patents.google.com/patent/US20090258815A1/en PatentUS 2009/0258815 A1
RECORD: Rec_0208550 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Fluorescein/FITC labeling
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperCyLoP-1: a novel cysteine-rich cell-penetrating peptide for cytosolic delivery of cargoes PMID21319732 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21319732/
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