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MYP_167259
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Basic Information
Beta-lactorphin
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Uric acid metabolism ▸ Hypouricemic activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Stimulation activity
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
4 amino acids
C26H34N4O6
Standard
Sequence
YGLF
Physicochemical Analysis
498.57 Da
5.52
-0.24
-0.45
-0.0602
1.23
0.24
0.75
-13.72
97.50
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
170.85
0.72
6.0
6.0
13.0
36.0
2.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0117841 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
PaperIdentification of bitter peptides in whey protein hydrolysate. J. Agric. Food Chem., 62, 5719-5725, 2014 PMID23998904 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23998904/
RECORD: Rec_0177306 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV inhibitory Antidiabetic
Dipeptidyl peptidase-IV (DPP-IV)
IC50
PaperBioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides | Pihlanto-Leppala, A. et al. | DOI: 10.1016/S0924-2244(01)00003-6 Evidence URLhttps://www.uniprot.org/uniprotkb/P00711/entry
RECORD: Rec_0190503 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
733.3
IC50
PaperMullally M. M., Meisel H., FitzGerald R. J.. Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-260, 1996.
RECORD: Rec_0191017 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hypouricemic
PaperQi X., Chen H., Guan K., Wang R., Ma Y.. Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats. J. Sci. Food Agric., 101, 4916-4924, 2021.
RECORD: Rec_0193959 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Mucin secretagogue Gastroprotective
HT29-MTX cells
Mucin secretion assay
PaperFood-Derived Peptides Stimulate Mucin Secretion and Gene Expression in Intestinal Cells | Martinez-Maqueda, D. et al. | DOI: 10.1021/jf301279k Evidence URLhttps://www.uniprot.org/uniprotkb/P00711/entry
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