Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length711 amino acids

Chemical FormulaC3536H5628N974O994S26

DescriptionStandard

        MSGDWQPSLGLETRLKVRRVRGGEVGIHNLGVKSWGTAPTDVKPRDESMAKLALTSVGPGHQPLGFACQQFGLELVKSLLKREHVPDLNGSYSIPLIGDVGYSVSRIQIQELQLNESVVSFSEGTGVRLVVSNAHMQLSGVWRVKVLFIPDSGSFDLSVRDLSLSAELGVSRDDNGRPQVWSTNCRSSIGRLDVKFHDGASWLYNLFTGALQAPLRYEVNRQLCPELGKGISDLERVLKTMQVSAQIDPFAAIDYSLVNKPVIARDHGDMDLKIPKRSPIRLNTGSMGLFFPELKKLYPDMPMELHLSARKQPLLTCRPDSLALALFGAAEAFVVLPNATLASAFLLDLLKKLYPDMPMELHLSARKQPLLTCRPDSLALALFGAAEAFVVLPNATLASAFLLDLDASLAGQLHLHSAKVGGSVALTDFSMSVVRSHIGSVQVKTLETLLKLALRMVALPMANKKLKKGFPLPSVYNVSLVNPRVKINQMLSLPALRVGTLARRGVLGTASIRAAHGHSGHVLLRSEADVPQGSAHRPGGTPGPIEVLAGFASDINGARISAQWLELFVATQEDMSVPRYYDKRSSPLPDVPYCKELGAEQKALKEKEKGSWKQLSNEEKVALYHLKFNQTFAQMNRPSNEWKTVLGGMFVFFGFTGLIVWWQRVYVFPPKPHTLTEEWKAQQVKRMLDMRMNPIQGFSAKWDYDKNEWKK
    

Molecular Weight78522.13 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)18.99

Net Charge (pH 7.4) 17.67

Charge Density (pH 7.0) 0.0267

GRAVY Index-0.10

Hydrophobic Moment 0.80

Boman Index0.05

Instability Index32.40

Aliphatic Index 95.30

Aromaticity 0.0774

Extinction Coeff. Reduced 92360.00

Extinction Coeff. Oxidized 92735.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0268509 VERIFIED: YES

Provenance & Taxonomy

OrganismChelonia mydas [Animal]

FamilyBPI/LBP

Tax ID8469

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria