Peptide Database

Peptide NameSLAY-screened peptide P4593

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC66H105N17O21S3

DescriptionStandard

        PCCSHTTCVTGLYIA
    

Molecular Weight1568.84 Da

Isoelectric Point (pI)7.04

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.14

Charge Density (pH 7.0) 0.0010

GRAVY Index0.83

Hydrophobic Moment 0.12

Boman Index0.34

Instability Index-17.07

Aliphatic Index 78.00

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 586.56

LogP -7.15

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 45.0

Heavy Atoms 107.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0209815 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/