Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2386H3748N610O715S13

DescriptionStandard

        MSLPQETSVSHNMRLFLAVIVLITPTSGETPAVHVSLTDKALHYGAYAGAQWMTDKLKDVSIPDISGEIYILFDNLHYTLMGITIENVKFPEPSVEFYPGRGLDASVSDVSVTLTGGWITRFGLIQDGGTFQMNVFNTDVTFAVQLGRGVGGHPFVTSVNCEAHVGGVDMQFHGGGSWIFQPFVSKYRDRVRGEIEDKICPQLEESIIKLDYRLQVFGVSINVSKDLTLDLGLTDDPVIDVSSLNVGLKGVIYSIKTHAEPPFAPQPFSLAEQPDSMLTLGVSEFTLNSASYAYYSAGLLQILLNDSMIPSYSPVHLNTSSFGAFIPQLPKMYPGLLMNLQLYAREVPVVSFQPGLVTLDLQGAVKAYAIQLTGAQIPLFTLNTDSKFSGKVWTAGGRLKGSAEMKNLTVTLQATEIGGFETAALENLARVGAKLAITKLNQRLRKGVELPRLKHAELTNTTLEVETGFITISTDAQISLTEDSTD
    

Molecular Weight52835.78 Da

Isoelectric Point (pI)5.13

Net Charge (pH 7.0)-14.58

Net Charge (pH 7.4) -15.45

Charge Density (pH 7.0) -0.0300

GRAVY Index0.09

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index34.80

Aliphatic Index 98.46

Aromaticity 0.0864

Extinction Coeff. Reduced 44350.00

Extinction Coeff. Oxidized 44475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0187111 VERIFIED: NO

Provenance & Taxonomy

OrganismTakifugu flavidus [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence