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MYP_167004
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Basic Information
P21
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
21 amino acids
C110H177N25O36S
Standard
Sequence
LDLTYEMLSLQQVVKALNESY
Physicochemical Analysis
2457.79 Da
4.14
-2.24
-2.45
-0.1065
0.06
0.61
0.12
34.84
125.24
0.0952
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1013.66
-7.59
34.0
35.0
83.0
172.0
2.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015169 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
1335626
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus
50 μM
EC50
PaperDiscovery of hydrocarbon-stapled short α-helical peptides as promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) fusion inhibitors PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0022677 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0307115 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | Huh-7 cells
50 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. | Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K. | J Med Chem. 2018 Mar 8;61(5):2018-2026. | DOI:10.1021/acs.jmedchem.7b01732 | PMID:29442512 PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0344189 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV:inhibition of cell-cell fusion in Huh-7 cells
50 μM
EC50
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0397582 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
MERS-CoV
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/