Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2346H3695N589O688S22

DescriptionStandard

        MLPSVIVVLTFLSCASGENPAMQVILTNKGLQYGKHAGAGLIQDKLENMTLPDITGDVDIKIGKVHYTLTGTTITKCDFPEPSVEFFNATGFKTSTSGLSVALAGEWRTRFGIIHDGGSFNMAIFSVDVTSVVQLGRDSNGHLSITSMSCDAVVGDVDIQFHGGASWIIQRFVHHFKGKIKGKMESNICPAVTESIEKLEFHLQAMNVSFDVNEVLYLDLPLTGLPLIDASRLNLGLKGEFYSIKTPTEPPFKPQPFTMPEQPAYMLSVGVSEFTLNSASFGYYSAGLLQVLIDDSMIPPSSPVHLNTTSMGVFIPQLPKKFPDLLMKLQVYAKEAPLFSFQSGAAKLSAQIDVKAFAIEPNSTQIPLFKLGVDSKFNSKWWFADETLKGSVALDNITLTLESTEVGDFKVDGLQKTLSMAMKVAVLPKLNGELGKGIALPRMKHAQLVNSVLKMEEGFMTVSSDAKLLMEDTRFN
    

Molecular Weight51864.40 Da

Isoelectric Point (pI)5.73

Net Charge (pH 7.0)-7.62

Net Charge (pH 7.4) -8.51

Charge Density (pH 7.0) -0.0160

GRAVY Index0.09

Hydrophobic Moment 0.64

Boman Index0.16

Instability Index32.42

Aliphatic Index 92.96

Aromaticity 0.0861

Extinction Coeff. Reduced 33920.00

Extinction Coeff. Oxidized 34170.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0089847 VERIFIED: NO

Provenance & Taxonomy

OrganismStegastes partitus [Bacterium]

FamilyBPI

Tax ID144197

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence