Peptide Database

Peptide NameSLAY-screened peptide P658

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC52H78N20O18S

DescriptionStandard

        RQHPQHACDPD
    

Molecular Weight1303.36 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.0973

GRAVY Index-2.16

Hydrophobic Moment 0.32

Boman Index-0.52

Instability Index92.09

Aliphatic Index 9.09

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 616.78

LogP -8.12

H-bond Donors 20.0

H-bond Acceptors 20.0

Rotatable Bonds 38.0

Heavy Atoms 91.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0368956 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/