Peptide Database

Peptide NameEcumicin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC75H120N14O16

DescriptionStandard

        VVITTVLVVWVFV
    

Molecular Weight1473.84 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-0.27

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0205

GRAVY Index2.94

Hydrophobic Moment 0.14

Boman Index0.92

Instability Index2.70

Aliphatic Index 216.15

Aromaticity 0.1538

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 468.77

LogP 1.63

H-bond Donors 17.0

H-bond Acceptors 16.0

Rotatable Bonds 42.0

Heavy Atoms 105.0

Ring Count 3.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325892 VERIFIED: YES

Provenance & Taxonomy

OrganismNonomuraea sp. [Bacterium]

FamilyNonribosomal peptide

Structure & Mods

Configmacrocyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermNone

Other ModsN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe

Bio-Activity Profile

Function

Antimicrobial Antimycobacterial

TargetMycobacterium smegmatis (ATCC 700084)

Activity1.7 μM

MethodMIC

RECORD: Rec_0340158 VERIFIED: YES

Provenance & Taxonomy

OrganismNonomuraea sp. [Bacterium]

FamilyNonribosomal peptide

Structure & Mods

Configmacrocyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermNone

Other ModsN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe

Bio-Activity Profile

Function

Antimicrobial Antimycobacterial

TargetMycobacterium chelonae (ATCC 35752)

Activity0.97 μM

MethodMIC

RECORD: Rec_0361937 VERIFIED: YES

Provenance & Taxonomy

OrganismNonomuraea sp. [Bacterium]

FamilyNonribosomal peptide

Structure & Mods

Configmacrocyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermNone

Other ModsN-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe

Bio-Activity Profile

Function

Antimicrobial Antimycobacterial

TargetMycobacterium tuberculosis H37Rv strains with monoresistance to isoniazid (INH) (ATCC 35822)

Activity0.12 μM

MethodMIC

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