Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length444 amino acids

Chemical FormulaC2189H3446N590O620S19

DescriptionStandard

        MRDEDMARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESSIRKTMNNKVGHAQSPGNGGGGDPGSPCLLCPQGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMIPKKSKFRLTTDFLGTLIPQVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLVRQMVVSASSSPSHRLLLELKHSDVGSFSVSLRTDLPSIAERLQEGFPLPMPKNVQLFNLVLQTHQDFLLFGADVHYSG
    

Molecular Weight48557.59 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)9.78

Net Charge (pH 7.4) 8.65

Charge Density (pH 7.0) 0.0220

GRAVY Index-0.00

Hydrophobic Moment 0.75

Boman Index0.12

Instability Index42.67

Aliphatic Index 91.13

Aromaticity 0.0833

Extinction Coeff. Reduced 33920.00

Extinction Coeff. Oxidized 34170.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0081072 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus dingo [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria