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MYP_166718
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
6 amino acids
C45H66N18O8
Standard
Sequence
RRWQWR
Physicochemical Analysis
987.12 Da
12.00
2.76
2.56
0.4600
-3.13
0.54
-1.14
199.27
0.00
0.3333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
469.19
-2.67
19.0
11.0
30.0
71.0
4.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0089562 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
7.5 μM
LD99
Human Serum: More than 70% of peptides remain intact after 6.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0090289 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37355
RECORD: Rec_0106475 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-Gram-positive
Bacillus subtilis
7.5 μM
LD99.99
Human serum, in vitro; <1800 s
PaperSerum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0119675 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
APD analysis reveals that this sequence is 71.43% similar to Combi-1 . R: 50%, W: 33%, Q: 17%
Bio-Activity Profile
Antimicrobial
Bacillus subtilis ATCC6633
7.5 μM
MIC
PaperThe structure of the antimicrobial active center of lactoferricin B bound to sodium dodecyl sulfate micelles.
RECORD: Rec_0123972 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Transferrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
64 μM
MIC
PMID35288606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35288606/
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