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MYP_166718
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
6 amino acids
C45H66N18O8
Standard
Sequence
RRWQWR
Physicochemical Analysis
987.12 Da
12.00
2.76
2.56
0.4600
-3.13
0.54
-1.14
199.27
0.00
0.3333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
469.19
-2.67
19.0
11.0
30.0
71.0
4.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0379269 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Transferrin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
25 μg/mL
MIC
PMID28752991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28752991/
RECORD: Rec_0385172 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
60 μM
LD99
Human Serum: Have half-lifes of ~1.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0387003 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
15 μM
LD99
Human Serum: Degraded quickly with half-lifes of less than 0.5 h and are completely gone after 2 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0392183 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
APD analysis reveals that this sequence is 71.43% similar to Combi-1 . R: 50%, W: 33%, Q: 17%
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus 42D
30 μM
MIC
PaperThe structure of the antimicrobial active center of lactoferricin B bound to sodium dodecyl sulfate micelles.
RECORD: Rec_0392189 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
>120 μM
LD99
Human Serum: Have half-lifes of about 1 h, still almost fully degraded after 2 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
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