Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length423 amino acids

Chemical FormulaC2099H3298N524O613S21

DescriptionStandard

        MLPSVMVVFAILSCTRAENPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDSGSFDMAIFSVSLTSVVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFMFQPFVDHYKDKIVSVIQSNICPNVQTAIDDLESHLQAMSISYDVNEVLTVELPLTSPPVISGDDVNLGLKGEFYSIETHQEPPFVAQPFVLPKEPNYMMSVGLSEFMLNSASFGYFSAGNLQVLVNDSMIPPKSPIHLNTTSMGMFIPQLPKLYPDMLMNLQVYATEAPMLSLQMDVVEVGAQLGAKAFAIEPNGTQVPLFTLSVETRLILTLTQKTTLLGDGIVLPQMKQAQLVNPVLKLEKVSFNQRMHINVV
    

Molecular Weight46355.15 Da

Isoelectric Point (pI)4.93

Net Charge (pH 7.0)-16.53

Net Charge (pH 7.4) -17.45

Charge Density (pH 7.0) -0.0391

GRAVY Index0.24

Hydrophobic Moment 0.58

Boman Index0.21

Instability Index42.53

Aliphatic Index 103.59

Aromaticity 0.0804

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31650.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0363532 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius furzeri [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence