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MYP_166415
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Basic Information
Peptide leucine arginine (pLR; Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ Granulopoiesis inhibition
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C99H153N27O22S2
Standard
Sequence
LVRGCWTKSYPPKPCFVR
Physicochemical Analysis
2137.57 Da
9.85
3.74
3.50
0.2076
-0.32
0.26
-0.08
18.71
53.89
0.1667
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
783.97
-4.92
30.0
28.0
62.0
150.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0329539 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Bacillus megaterium Bm11
20 μM
MIC
PMID11099505 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11099505/
RECORD: Rec_0373339 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Ranacyclin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
C. tropicalis
11 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0374255 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Ranacyclin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Micrococcus luteus
10 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0380949 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
PMID11099505 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11099505/
RECORD: Rec_0388223 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-15
Bio-Activity Profile
Antimicrobial Antifungal Immunomodulatory
C. tropicalis
11 μM
MIC
PaperPeptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens.
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