‹ ›
MYP_166415
← PREVIOUS NEXT → BACK
Basic Information
Peptide leucine arginine (pLR; Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ Granulopoiesis inhibition
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C99H153N27O22S2
Standard
Sequence
LVRGCWTKSYPPKPCFVR
Physicochemical Analysis
2137.57 Da
9.85
3.74
3.50
0.2076
-0.32
0.26
-0.08
18.71
53.89
0.1667
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
783.97
-4.92
30.0
28.0
62.0
150.0
7.0
17.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0020010 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Micrococcus luteus
10 μM
MIC
PMID11099505 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11099505/
RECORD: Rec_0034669 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Phytophthora nicotianae spores
75 μM
MIC
PMID11099505 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11099505/
RECORD: Rec_0040722 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Ranacyclin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
C. guillermondii
6.6 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0041215 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Leucine arginine
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
5-15
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Mast cell degranulation Granulopoiesis inhibition Histamine releasing
PaperA.L. Salmon et al. / Journal of Biological Chemistry 276 (2001) 10145-10152. Peptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens Evidence URLhttps://www.uniprot.org/uniprotkb/Q90WP7/entry
RECORD: Rec_0045098 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
frog skin active peptide (FSAP) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
5-15
Bio-Activity Profile
Antimicrobial frog skin active peptide (FSAP) family Antifungal Host defense
PaperPDB 2M3N structural record; NMR; chain A; residues 1-18
1 2 3 ... 6 NEXT LAST
Showing 5 records on this page · Page 1 of 6