Peptide Database

Peptide NameCADY-2b (SEQ ID No: 9)

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC129H202N40O24

DescriptionStandard

        GLWRALWRALWRSLWKSKRKV
    

Molecular Weight2697.24 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.3218

GRAVY Index-0.59

Hydrophobic Moment 0.83

Boman Index-0.22

Instability Index87.03

Aliphatic Index 97.62

Aromaticity 0.1905

Extinction Coeff. Reduced 22000.00

Extinction Coeff. Oxidized 22000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1074.60

LogP -4.07

H-bond Donors 43.0

H-bond Acceptors 31.0

Rotatable Bonds 88.0

Heavy Atoms 193.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0163035 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

RECORD: Rec_0290436 VERIFIED: NO

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetHeLa; HS-68 cells

MethodCellular uptake assay

RECORD: Rec_0367496 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermCysteamide group

Bio-Activity Profile

Function

Drug Delivery Vehicle Cell-penetrating peptide

RECORD: Rec_0385370 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anticancer

PaperSelf-assembled peptide (CADY-1) improved the clinical application of doxorubicin.; Modeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo. PMID22688249;23000699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22688249/ PatentUS7943581B2