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MYP_166346
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Basic Information
Jindongenin-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C131H226N38O39S3
Standard
Sequence
GFMDTAKNVAKNVAVTLIDKLRCKVTGGC
Physicochemical Analysis
3053.62 Da
9.31
2.74
2.50
0.0944
0.23
0.61
0.05
-2.20
90.69
0.0345
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1265.57
-13.83
46.0
45.0
105.0
211.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027980 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Jindongenin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
135.0 μM
HC50
PaperZ. Chen et al. / Biochimie 94 (2012) 328-334. Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis Evidence URLhttps://www.uniprot.org/uniprotkb/G3ETQ3/entry
RECORD: Rec_0050030 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-29
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
13 μM
MIC
PaperTwo novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis
RECORD: Rec_0052403 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus dysenteriae
50 μM
MIC
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
RECORD: Rec_0074404 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-29
Bio-Activity Profile
Antimicrobial
Klebsiella pneumoniae IS 59#
50 μM
MIC
PaperTwo novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis
RECORD: Rec_0075588 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Jindongenin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
20.0 μM
MIC
PaperZ. Chen et al. / Biochimie 94 (2012) 328-334. Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis Evidence URLhttps://www.uniprot.org/uniprotkb/G3ETQ3/entry
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