Peptide Database

Peptide NameTachyplesin ccTP [4,8R]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC89H149N35O20S6

DescriptionStandard

        KWCRCVCRRGICYCRCRG
    

Molecular Weight2221.75 Da

Isoelectric Point (pI)9.49

Net Charge (pH 7.0)5.70

Net Charge (pH 7.4) 5.41

Charge Density (pH 7.0) 0.3166

GRAVY Index-0.32

Hydrophobic Moment 0.64

Boman Index-0.44

Instability Index22.93

Aliphatic Index 37.78

Aromaticity 0.1111

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 929.56

LogP -9.70

H-bond Donors 43.0

H-bond Acceptors 32.0

Rotatable Bonds 72.0

Heavy Atoms 150.0

Ring Count 3.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0408803 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetEnterococcus faecalis ATCC 29212

Activity1 μM

MethodMIC

RECORD: Rec_0419777 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetKlebsiella oxytoca ATCC 49131

Activity6.1 μM

MethodMIC

RECORD: Rec_0420525 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetMicrococcus luteus ATCC 49732

Activity0.7 μM

MethodMIC

RECORD: Rec_0424976 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide3-16; 5-14; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetlow-salt; MIC=1.9 μM in high-salt)

Activity1.1 μM

MethodMIC

PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/

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