‹ ›
MYP_166262
← PREVIOUS NEXT → BACK
Basic Information
Tachyplesin ccTP [4,8R]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
18 amino acids
C89H149N35O20S6
Standard
Sequence
KWCRCVCRRGICYCRCRG
Physicochemical Analysis
2221.75 Da
9.49
5.70
5.41
0.3166
-0.32
0.64
-0.44
22.93
37.78
0.1111
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
929.56
-9.70
43.0
32.0
72.0
150.0
3.0
17.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0005861 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida tropicalis ATCC 37097
4.2 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0030899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 29213
1.3 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0058919 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
low-salt; MIC=2.0 μM in high-salt)
9.8 μM
MIC
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0072531 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 37092
11.2 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0113274 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 37092
6.4 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
1 2 3 ... 7 NEXT LAST
Showing 5 records on this page · Page 1 of 7