Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2409H3845N613O672S17

DescriptionStandard

        MLYSFLCVSELKMFPWRWLALLALIPLSLSANAGVKVKLTQKGLDFGRELFVASLQEKLMTIKVPDISGTERVDPIGKVHYSLTEMRIVKLGLPSSAIGLVPGTGFTMTITNAFLSLHGKWRVKYLRFIKDSGSFDLAIKSLSITTSISLRSDETGRPAVAVASCATTLGGVSIKFHGGASWLYNLFTRFIEKGLCSSLQKQICPLVAESVSSMNQFLKTLNVLAPLDRYAEIAYPMVSSPEISNSSIGLNLKGEFYNIGHHMEPPFSPAPFFLPNQEQSMLYIGLSVFTANSASFVYNKAGTLSLNITDDMIPPSSPFRLTTRTFGAFIPQIAKLFPGLMMVLQVKTAKDPLFNIEANNVTVDAISSLTAYAILANTSLAPLFVLNVDSSVGARVNVVGNKLAGAVNLNKLDMSLGKSYVGDFQVGPLHNIFQIVLKVAVLPRVNVRLKEGFPLPSLGKINLTNTQLQVLKGYILIGTDLQISG
    

Molecular Weight52692.11 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)13.00

Net Charge (pH 7.4) 12.33

Charge Density (pH 7.0) 0.0268

GRAVY Index0.32

Hydrophobic Moment 0.73

Boman Index0.20

Instability Index38.93

Aliphatic Index 108.54

Aromaticity 0.0887

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0304475 VERIFIED: NO

Provenance & Taxonomy

OrganismGadus morhua [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence