Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length565 amino acids

Chemical FormulaC2835H4431N723O838S22

DescriptionStandard

        MSTSKQGSLRAIWECGYHRGSGNNDGEGEFKAQVENTSTSKAEGIEGASQLWTLPLFEMCSKMAQVLWGCLLLWNLHISPAYSMYPGIKARATQRALDYGVQVGMEIIEQMVKKRDIPNLNGSESLEFLKVDYVNYNFTNIKINAFSFPNTSLAFVPGVGIRALTNHGTANISTDWEIKSPLFRDTGGADLFLSEVYFTGNVILTRNNFGHPILKLQDCHAQVSHADVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPMVTSEVEALNANLSMLEVITKIDNYTLLDYSLISSPDITENYIELYLKGVFYPLGNLTDPPFSSVPFVLPDRSDSMLYIGISEYFFKSASYAYFTAGAFNITLSTKEITDHLIRTSQGLGNMLSRIAELYILSQPFMVRVMATEPPLINLLPGNFTLDIPASIMILTQSKNSTAETIVSMDFVASTDVALVILGQRLICSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGILPLANAKLQQGLPLPNPHKISLVSSDIEVLEGFLLISTDLKYETSLKQQPSFHGWESLNLISGQWRGKPAP
    

Molecular Weight62756.28 Da

Isoelectric Point (pI)5.27

Net Charge (pH 7.0)-13.61

Net Charge (pH 7.4) -14.55

Charge Density (pH 7.0) -0.0241

GRAVY Index0.04

Hydrophobic Moment 0.67

Boman Index0.14

Instability Index41.62

Aliphatic Index 99.24

Aromaticity 0.0956

Extinction Coeff. Reduced 66810.00

Extinction Coeff. Oxidized 67185.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0085200 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI

Tax ID9823

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence