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MYP_166158
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Basic Information
[Lys6] TG
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XGLXGKLXGIX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0184057 VERIFIED: YES
Provenance & Taxonomy
Ascomycetes [Fungus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID25306964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25306964/
RECORD: Rec_0186844 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0205531 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1)=TOAC; X(4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: T67
1 μM
EC50
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0235160 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1)=TOAC; X(4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
3 μM
EC50
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0238464 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
T67
4 μM
EC50
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
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