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MYP_166012
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Basic Information
Ocellatin-4 (Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C107H175N25O29
Standard
Sequence
GLLDFVTGVGKDIFAQLIKQI
Physicochemical Analysis
2275.68 Da
5.96
-0.24
-0.45
-0.0114
0.81
0.62
0.35
-3.02
143.81
0.0952
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
878.37
-4.80
29.0
29.0
78.0
161.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017838 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus ocellatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
64 μM
MIC
PMID17884127 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17884127/
RECORD: Rec_0038016 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0092960 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus bolivianus [Animal]
Ocellatin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
64.0 μM
MIC
PaperA. Nascimento et al. / Toxicon 50 (2007) 1095-1104. Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus Evidence URLhttps://www.uniprot.org/uniprotkb/P85090/entry
RECORD: Rec_0096211 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus ocellatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID17884127 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17884127/
RECORD: Rec_0133894 VERIFIED: NO
Provenance & Taxonomy
Amphibia [Animal]
Ocellatin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
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