Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length484 amino acids

Chemical FormulaC2462H3899N629O679S15

DescriptionStandard

        EDMARGPDTARRWATLVVLAALGTAVTTTNPGIVARITQKGLDYACQQGVLTLQKELEKITIPNFSGNFKIKYLGKGQYSFFSMVIQGFNIPNSQIRPLPDKGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISILAGLNLGYDPASGHSTVTCSSCSSGINTVRIHISGSSLGWLIQLFRKRIESLLQKSMTRKICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRATANNLDWLLKGEFFSLAHRSPPPFAPPALAFPSDHDRMVYLGISEYFFNTAGFVYQKAGALNLTLRDDMIPKESKFRLTTKFFGILIPQVAKMFPDMQMQLFIWASLPPKLTMKPSGLDLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGAKSDRLIGELRLDKLLLELKHSDIGPFSVESLQSVINYVMPTIVLPVINKKLQKGFPLPLPAYIELFNLTLQPYQDFLLFGADVHYS
    

Molecular Weight53655.08 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)13.34

Net Charge (pH 7.4) 12.70

Charge Density (pH 7.0) 0.0276

GRAVY Index0.11

Hydrophobic Moment 0.69

Boman Index0.13

Instability Index34.16

Aliphatic Index 103.35

Aromaticity 0.0971

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207344 VERIFIED: NO

Provenance & Taxonomy

OrganismBos mutus [Animal]

FamilyBPI/LBP

Tax ID30521

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence