Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length531 amino acids

Chemical FormulaC2620H4124N704O742S19

DescriptionStandard

        MPAKHAPPPHTHTQTCVHTHMSHAHLLPLTPQLPGSTLGPNHGRQQPSPSPAPTQFPSSFLHPTGLHFPSQLLYRSLAPLQGLKALAALEDEDMARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESSIRKTMNNKICQVVSSSVSSRLQSYLKTLPVTYKIDRIAGISYSLVAPPTATADNLDGHLKGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMIPKKSKFRLTTDFLGTLIPQVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLSTNLSMEVSARPDRLVGQLSLDKLLLELKHSDVGSFSDFLLFGADVHYSG
    

Molecular Weight57966.28 Da

Isoelectric Point (pI)9.36

Net Charge (pH 7.0)13.47

Net Charge (pH 7.4) 11.93

Charge Density (pH 7.0) 0.0254

GRAVY Index-0.03

Hydrophobic Moment 0.75

Boman Index0.12

Instability Index39.81

Aliphatic Index 91.85

Aromaticity 0.0791

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0333543 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria