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MYP_165597
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Basic Information
Salivaricin 9 (Sal9; Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
24 amino acids
C114H190N32O33S3
Standard
Sequence
GNGVVLTLTHECNLATWTKKLKCC
Physicochemical Analysis
2633.12 Da
8.66
1.82
1.51
0.0757
0.12
0.38
0.09
-1.51
93.33
0.0417
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1059.55
-10.67
40.0
39.0
87.0
182.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021707 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Streptococcus pyogenes and some Enterococci
PaperPubMed PMID: 21310787 PMID21310787 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21310787/
RECORD: Rec_0071891 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0092074 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 29.2%, E 0.0%, T 25.0%, C 45.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0104036 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Calcualted molecular weight of sequence before modification is 2633.147. Reported as a 2560 Da lantibiotic
Bio-Activity Profile
Antimicrobial
Corynebacterium spp GH17
8 μM
MIC
PaperEnhanced Production, Purification, Characterization and Mechanism of Action of Salivaricin 9 Lantibiotic Produced by Streptococcus salivarius NU10
RECORD: Rec_0243461 VERIFIED: YES
Provenance & Taxonomy
Streptococcus salivarius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Calcualted molecular weight of sequence before modification is 2633.147. Reported as a 2560 Da lantibiotic
Bio-Activity Profile
Antimicrobial
S. pyogenes ATCC 12344, S. pyogenes ATCC 12384
32 μM
MIC
PaperEnhanced Production, Purification, Characterization and Mechanism of Action of Salivaricin 9 Lantibiotic Produced by Streptococcus salivarius NU10
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