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MYP_165560
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Basic Information
hLF
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C56H95N25O14S
Standard
Sequence
GRRRRSVQWCA
Physicochemical Analysis
1374.58 Da
12.00
3.75
3.53
0.3409
-1.37
0.18
-0.72
205.25
35.45
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
681.03
-8.48
28.0
19.0
45.0
96.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055012 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Lactoferrin-derived
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial Antifungal Immunomodulatory
antibiotic-resistant Staphylococcus aureus and Klebsiella pneumoniae (in vitro and murine infection models)
PaperHuman lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria PMID11179314 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11179314/
RECORD: Rec_0058727 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Lactoferricin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium avium strain 2447 smooth transparent variant (SmT)
MIC
PMID24709266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24709266/
RECORD: Rec_0076101 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
PMID11179314;24704699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11179314/
RECORD: Rec_0091638 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Lactoferricin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium avium 2-151 smT
19.13 μM
MIC
PMID24709266 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24709266/
RECORD: Rec_0094739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Streptococcus sanguinis
100, 200, 50 μM
Total countable CFUs
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