Peptide Database

Peptide NameProkineticin Bv8-like peptide 2

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC338H543N105O108S10

DescriptionStandard

        AVITGACDRDVQCGSGTCCAASLWSRNIRFCVPLGNNGEECHPASHKVPYNGKRLSSLCPCKSGLTCSKSGEKFQCS
    

Molecular Weight8126.22 Da

Isoelectric Point (pI)8.60

Net Charge (pH 7.0)3.88

Net Charge (pH 7.4) 3.43

Charge Density (pH 7.0) 0.0503

GRAVY Index-0.26

Hydrophobic Moment 0.58

Boman Index-0.04

Instability Index47.21

Aliphatic Index 57.01

Aromaticity 0.0519

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3418.87

LogP -47.91

H-bond Donors 129.0

H-bond Acceptors 124.0

Rotatable Bonds 265.0

Heavy Atoms 561.0

Ring Count 11.0

Amide Bonds 82.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0045359 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bv8-like peptide

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Targetguinea-pig gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0208481 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bv8-like peptide

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

TargetDRG neurons

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0421144 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bv8-like peptide

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour