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MYP_165394
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Standard
35 amino acids
C185H282N50O45S4
Standard
Sequence
FHFEVFNFVPCSICSNNPTCWAICKRIPNKKPGKK
Physicochemical Analysis
4054.79 Da
9.44
4.81
4.48
0.1373
-0.28
0.46
-0.00
18.13
52.86
0.1429
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1524.38
-12.97
54.0
55.0
127.0
284.0
11.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010643 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 28.6%, E 0.0%, T 17.1%, C 54.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0119907 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0217684 VERIFIED: YES
Provenance & Taxonomy
Human orthopneumovirus [Virus]
Virus-derived peptide
11250;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Cytoprotective
Respiratory syncytial virus (Cytopathic effect); HEp-2
80 μM
NMR
PaperAntiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein. | Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. | J Biol Chem. 2001 | PMID:11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0337290 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
Respiratory syncytial virus(RSV):inhibition of the cytopathic effect of RSV in HEp-2 cells
80 μM
IC50
PaperPubMed PMID: 11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0344878 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The peptide formed two disulfide bonds.
Bio-Activity Profile
Antiviral Anti-RSV Entry inhibition
Respiratory syncytial virus(RSV) | HEp-2 cells
80 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein. | Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. | J Biol Chem. 2001 Oct 19;276(42):38988-94. | DOI:10.1074/jbc.M106288200 | PMID:11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/