Peptide Database

Peptide NameEndokinin-A

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC221H349N55O76S

DescriptionStandard

        DGGEEQTLSTEAETWVIVALEEGAGPSIQLQLQEVKTGKASQFFGLM
    

Molecular Weight5024.52 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-6.22

Net Charge (pH 7.4) -6.44

Charge Density (pH 7.0) -0.1324

GRAVY Index-0.17

Hydrophobic Moment 0.34

Boman Index0.14

Instability Index44.60

Aliphatic Index 85.11

Aromaticity 0.0638

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2116.42

LogP -22.06

H-bond Donors 70.0

H-bond Acceptors 71.0

Rotatable Bonds 171.0

Heavy Atoms 353.0

Ring Count 5.0

Amide Bonds 51.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0236056 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyEndokinin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Receptor modulation

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour