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MYP_165346
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Basic Information
Ranatuerin-2CHb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
28 amino acids
C125H224N34O37S3
Standard
Sequence
GLMDTIKGVAKNVAASLLEKLKCKVTGC
Physicochemical Analysis
2891.52 Da
9.24
2.74
2.50
0.0978
0.40
0.59
0.11
-16.95
111.43
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1157.50
-11.13
42.0
43.0
103.0
199.0
0.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0290045 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Klebsiella pneumoniae
80 μM
MIC
RECORD: Rec_0312232 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Ranatuerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
RECORD: Rec_0317296 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
20.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 32 (2011) 664-669. Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona
RECORD: Rec_0346251 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0353800 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
80.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 32 (2011) 664-669. Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona
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