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MYP_165336
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Basic Information
Lantibiotic michiganin-A (Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
21 amino acids
C92H153N25O30S4
Standard
Sequence
SSSGWLCTLTIECGTIICACR
Physicochemical Analysis
2217.61 Da
5.71
-0.58
-0.84
-0.0275
0.89
0.16
0.28
113.87
97.62
0.0476
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
881.69
-10.70
37.0
34.0
70.0
151.0
2.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027426 VERIFIED: YES
Provenance & Taxonomy
Clavibacter michiganensis subsp. Michiganensis [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
All of the threonine residues undergo dehydration, and three of them interact with cysteines via thioether bonds to form methyllanthionine bridges
Bio-Activity Profile
Antimicrobial Antibacterial
Clavibacter michiganensis subspecies sepedonicus strain 2136
0.03 μM
MIC
PMID16957199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16957199/
RECORD: Rec_0163077 VERIFIED: YES
Provenance & Taxonomy
Clavibacter michiganensis subsp. michiganensis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
S.michiganensis subspecies sepedonicus strain 2136
30
MIC
PMID16957199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16957199/
RECORD: Rec_0226795 VERIFIED: YES
Provenance & Taxonomy
Clavibacter michiganensis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0241375 VERIFIED: YES
Provenance & Taxonomy
Clavibacter michiganensis [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID20226050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20226050/
RECORD: Rec_0247464 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 28.6%, T 38.1%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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