Peptide Database

Peptide NameR-spondin-2

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length220 amino acids

Chemical FormulaC1085H1728N354O312S27

DescriptionStandard

        NRWRRNKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKRNKKKRRKLIERAQEQHSVFLATDRVNQ
    

Molecular Weight25589.27 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)24.09

Net Charge (pH 7.4) 23.19

Charge Density (pH 7.0) 0.1095

GRAVY Index-0.94

Hydrophobic Moment 0.64

Boman Index-0.31

Instability Index61.06

Aliphatic Index 40.36

Aromaticity 0.0864

Extinction Coeff. Reduced 29450.00

Extinction Coeff. Oxidized 30825.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152624 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of aspragine residue at position 137; predicted disulphide bond formation between cysteine residues at positions 122 and 164; 133 and 140, and 173 and 180

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR6 (Human)

Activity0.5 nM

MethodIC50