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MYP_165169
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Basic Information
HPA3NT3-A2 (HPA3NT3 peptide analogs)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C94H161N27O16
Standard
Sequence
AKRLKKLAKKIWKWK
Physicochemical Analysis
1925.46 Da
11.47
7.79
7.59
0.5193
-1.19
0.83
-0.44
14.09
91.33
0.1333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
746.34
-1.02
28.0
24.0
71.0
137.0
4.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0359814 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HPA3
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-Lys at 2nd, 5th, 6th, 9th, 10th, 13th, and 15th position
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus PBEL 1
4 μM
MIC
Remaining 100% more than 120 min
PaperLee JK, Park Y All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance Int J Mol Sci. 2020 Aug 6;21(16):5632. PMID:32781586 https://pubmed.ncbi.nlm.nih.gov/32781586/ PMID32781586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32781586/
RECORD: Rec_0366984 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Listeria monocytogenes
2 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0374756 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HPA3
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
D-Lys at 2nd, 5th, 6th, 9th, 10th, 13th, and 15th position
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
4 μM
MIC
Remaining 100% more than 120 min
PaperLee JK, Park Y All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance Int J Mol Sci. 2020 Aug 6;21(16):5632. PMID:32781586 https://pubmed.ncbi.nlm.nih.gov/32781586/ PMID32781586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32781586/
RECORD: Rec_0387641 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
T. beigelii
16 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0395118 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
32 μM
MIC
Unspecified 60 min
PaperAntimicrobial peptide HPA3NT3-A2 effectively inhibits biofilm formation in mice infected with drug-resistant bacteria.
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